Dr. Sabine Middelhaufe
School of Biosciences
University of Exeter

Research interests:
Microbial production of hydrocarbons
Metabolic engineering
Signaling and metabolic regulation

PhD thesis

"Investigations on the domain architecture and regulation of human soluble adenylyl cyclase and the human phosphodiesterase h-Prune"

in the lab of Prof. Dr. Clemens Steegborn
Department of Physiological Chemistry
Ruhr-Universität Bochum


Schlicker C, Hall RA, Vullo D, Middelhaufe S, Gertz M, Supuran CT, Mühlschlegel FA, Steegborn C.
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans
(2009) J. Mol. Biol. 385(4), 1207-20

Middelhaufe, S., Garzia, L., Ohndorf, U., Kachholz, B., Zollo, M., and Steegborn, C.
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain.
(2007) Biochem J 407(2), 199-205

Kamenetsky, M., Middelhaufe, S., Bank, E. M., Levin, L. R., Buck, J., and Steegborn, C.
Molecular details of cAMP generation in mammalian cells: a tale of two systems
(2006) J. Mol. Biol. 362, 623-639